Often called the First American Serial Killer, Lavinia Fisher ran a guest house called the Six Mile Wayfarer House. After questioning guests over dinner in regards to assets and occupation, she'd send them up to bed with a cup of tea -- a poisoned cup of tea. She waited until the victim was unconscious, at which point a lever was pulled and the bed would fall through a trap door into the cellar, where her husband John was waiting with an axe.
Since she and John were quite popular in town police dismissed reports of missing guests, and she was able to continue killing for years.
Before her execution in 1820, Fisher is reported to have said, "If anyone has a message for the devil, give it to me!"